Publications

* authors contributed equally

E-Cigarette Use, Cigarette Smoking, and Sex are Associated with Nasal Microbiome Dysbiosis.

Authors: Hickman E*, Roca C*, Zorn BT, Rebuli ME, Robinette C, Wolfgang MC* & Jaspers I*
Reference: Nicotine Tob Res. 2024 Jul 17; .

Mucus polymer concentration and in vivo adaptation converge to define the antibiotic response of Pseudomonas aeruginosa during chronic lung infection.

Authors: Greenwald MA, Meinig SL, Plott LM, Roca C, Higgs MG, Vitko NP, Markovetz MR, Rouillard KR, Carpenter J, Kesimer M, Hill DB, Schisler JC, Wolfgang MC
Reference: mBio. 2024 Apr 23; e0345123.

Saliva sampling method influences oral microbiome composition and taxa distribution associated with oral diseases.

Authors: Roca C*, Alkhateeb AA*, Deanhardt BK, Macdonald JK, Chi DL, Wang JR, Wolfgang MC
Reference: PLoS One. 2024 Mar 28; 19(3):e0301016.

Longitudinal changes in the cystic fibrosis airway microbiota with time and treatment.

Authors: Einarsson GG*, Sherrard LJ*, Hatch JE, Zorn B, Johnston E, McGettigan C, O’Neill K, Gilpin DF, Downey DG, Murray M, Lavelle G, McElvaney G, Wolfgang MC, Boucher R, Muhlebach MS, Bradbury I, Elborn JS* & Tunney MM*
Reference: J Cyst Fibros. 2024 May 17; 23(2):252-261.

Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes.

Authors: Zhang Y, Bharathi V, Dokoshi T, de Anda J, Ursery LT, Kulkarni NN, Nakamura Y, Chen J, Luo EWC, Wang L, Xu H, Coady A, Zurich R, Lee MW, Matsui T, Lee H, Chan LC, Schepmoes AA, Lipton MS, Zhao R, Adkins JN, Clair GC, Thurlow LR, Schisler JC, Wolfgang MC, Hagan RS, Yeaman MR, Weiss TM, Chen X, Li MMH, Nizet V, Antoniak S, Mackman N, Gallo RL, Wong GCL
Reference: Proc Natl Acad Sci. 2024 Feb 06; 121(6):e2300644120.

Hyperglycemia potentiates increased Staphylococcus aureus virulence and resistance to growth inhibition by Pseudomonas aeruginosa.

Authors: Genito CJ*, Darwitz BP*, Greenwald MA, Wolfgang MC, Thurlow LR
Reference: Microbiol Spectrum. 2023 Dec 12; 11(6):e0229923.

A Novel Co-Culture Model Reveals Enhanced CFTR Rescue in Primary Cystic Fibrosis Airway Epithelial Cultures with Persistent Pseudomonas aeruginosa Infection.

Authors: Cholon DM*, Greenwald MA*, Higgs MG, Quinney NL, Boyles SE, Meinig SL, Minges JT, Chaubal A, Tarran R, Ribeiro CMP, Wolfgang MC* & Gentzsch M*
Reference: Cells. 2023 Nov 13; 12(22):2618.

Revisiting Host-Pathogen Interactions in Cystic Fibrosis Lungs in the Era of CFTR Modulators.

Authors: Ribeiro CMP, Higgs MG, Muhlebach MS, Wolfgang MC, Borgatti M, Lampronti I, Cabrini G
Reference: Int J Mol Sci. 2023 Mar 5; 24(5):5010.

The changing landscape of the cystic fibrosis lung environment: From the perspective of Pseudomonas aeruginosa.

Authors: Greenwald MA & Wolfgang MC
Reference: Curr Opin Pharmacol. 2022 Aug 1; 65:102262.

Cystic Fibrosis Airway Mucus Hyperconcentration Produces a Vicious Cycle of Mucin, Pathogen, and Inflammatory Interactions that Promote Disease Persistence.

Authors: Batson B, Zorn B, Radicioni G, Livengood S, Kumagai T, Dang H, Ceppe A, Clapp P, Tunney M, Elborn S, McElvaney G, Muhlebach M, Boucher RC, Tiemeyer M, Wolfgang M, Kesimer M
Reference: Am J Respir Cel Mol Biol. 2022 Apr 29; 67(2):253-265.

Protease-Anti-Protease Compartmentalization in SARS-CoV-2 ARDS: Therapeutic Implications.

Authors: McElvaney OF, Asakura T, Meinig SL, Torres-Castillo JL, Hagan RS, Gabillard C, Murphy MP, Thorne LB, Borczuk A, Reeves EP, Zumwalt RE, Mikami Y, Carroll TP, Okuda K, Hogan G, McElvaney OJ, Clarke J, McEvoy NL, Mallon PW, McCarthy C, Curley G, Wolfgang MC, Boucher RC, McElvaney NG.
Reference: eBioMedicine. 2022 Feb 22; 77:103894.

Global Regulatory Pathways Converge To Control Expression of Pseudomonas aeruginosa Type IV Pili.

Authors: Coggan KA, Higgs MG, Brutinel ED, Marden JN, Intile PJ, Winter-Larson HC, Koomey MJ, Yahr TL, Wolfgang MC.
Reference: mBio. 2022 Feb 22; 13(1):e0369621.

Role of miR-2392 in driving SARS-CoV-2 infection.

Authors: McDonald JT, Enguita FJ, Taylor D, Griffin RJ, Priebe W, Emmett MR, Sajadi MM, Harris AD, Clement J, Dybas JM, Aykin-Burns N, Guarnieri JW, Singh LN, Grabham P, Baylin SB, Yousey A, Pearson AN, Corry PM, Saravia-Butler A, Aunins TR, Sharma S, Nagpal P, Meydan C, Foox J, Mozsary C, Cerqueira B, Zaksas V, Singh U, Wurtele ES, Costes SV, Davanzo GG, Galeano D, Paccanaro A, Meinig SL, Hagan RS, Bowman NM; UNC COVID-19 Pathobiology Consortium, Wolfgang MC, Altinok S, Sapoval N, Treangen TJ, Moraes-Vieira PM, Vanderburg C, Wallace DC, Schisler JC, Mason CE, Chatterjee A, Meller R, Beheshti A.
Reference: Cell Rep. 2021 Sep 30; 37(3):109839.

Cautionary notes on the use of arabinose- and rhamnose-inducible expression vectors in Pseudomonas aeruginosa.

Authors: Williams McMackin EA, Corley JM, Karash S, Marden J, Wolfgang MC, Yahr TL.
Reference: J Bacteriol. 2021 Jul 22; 203(16):JB0022421.

SARS-CoV-2 infection of the oral cavity and saliva.

Authors: Huang N*, Pérez P*, Kato T, Mikami Y, Okuda K, Gilmore RC, Conde CD, Gasmi B, Stein S, Beach M, Pelayo E, Maldonado JO, Lafont BA, Jang SI, Nasir N, Padilla RJ, Murrah VA, Maile R, Lovell W, Wallet SM, Bowman NM, Meinig SL, Wolfgang MC, Choudhury SN, Novotny M, Aevermann BD, Scheuermann RH, Cannon G, Anderson CW, Lee RE, Marchesan JT, Bush M, Freire M, Kimple AJ, Herr DL, Rabin J, Grazioli A, Das S, French BN, Pranzatelli T, Chiorini JA, Kleiner DE, Pittaluga S, Hewitt SM, Burbelo PD, Chertow D, Frank K, Lee J, Boucher RC, Teichmann SA, Warner BM, Byrd KM.
Reference: Nat Med. 2021 May; 27(5):892-903.

Host Adaptation Predisposes Pseudomonas aeruginosa to Type VI Secretion System-Mediated Predation by the Burkholderia cepacia Complex.

Authors: Perault AI, Chandler CE, Rasko DA, Ernst RK, Wolfgang MC, Cotter PA.
Reference: Cell Host Microbe. 2020 Oct 7; 28(4):534-547.e3.

One-hit wonder: Late after burn injury, granulocytes can clear one bacterial infection but cannot control a subsequent infection.

Authors: Kartchner LB, Gode CJ, Dunn JLM, Glenn LI, Duncan DN, Wolfgang MC, Cairns BA, Maile R.
Reference: Burns. 2019 May; 45(3):627-640.

Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis.

Authors: Esther CR Jr, Muhlebach MS, Ehre C, Hill DB, Wolfgang MC, Kesimer M, Ramsey KA, Markovetz MR, Garbarine IC, Forest MG, Seim I, Zorn B, Morrison CB, Delion MF, Thelin WR, Villalon D, Sabater JR, Turkovic L, Ranganathan S, Stick SM, Boucher RC.
Reference: Sci Transl Med. 2019 Apr 3; 11(486).

RsmV, a Small Noncoding Regulatory RNA in Pseudomonas aeruginosa That Sequesters RsmA and RsmF from Target mRNAs.

Authors: Janssen KH, Diaz MR, Gode CJ, Wolfgang MC, Yahr TL.
Reference: J Bacteriol. 2018 Aug 15; 200(16).

Anaerobic bacteria cultured from cystic fibrosis airways correlate to milder disease: a multisite study.

Authors: Muhlebach MS, Hatch JE, Einarsson GG, McGrath SJ, Gilipin DF, Lavelle G, Mirkovic B, Murray MA, McNally P, Gotman N, Davis Thomas S, Wolfgang MC, Gilligan PH, McElvaney NG, Elborn JS, Boucher RC, Tunney MM.
Reference: Eur Respir J. 2018 Jul; 52(1).

Functional Analyses of the RsmY and RsmZ Small Noncoding Regulatory RNAs in Pseudomonas aeruginosa.

Authors: Janssen KH, Diaz MR, Golden M, Graham JW, Sanders W, Wolfgang MC, Yahr TL.
Reference: J Bacteriol. 2018 Jun 1; 200(11).

Evaluation of e-liquid toxicity using an open-source high-throughput screening assay.

Authors: Sassano MF, Davis ES, Keating JE, Zorn BT, Kochar TK, Wolfgang MC, Glish GL, Tarran R.
Reference: PLoS Biol. 2018 Mar; 16(3):e2003904.

Initial acquisition and succession of the cystic fibrosis lung microbiome is associated with disease progression in infants and preschool children.

Authors: Muhlebach MS, Zorn BT, Esther CR, Hatch JE, Murray CP, Turkovic L, Ranganathan SC, Boucher RC, Stick SM, Wolfgang MC.
Reference: PLoS Pathog. 2018 Jan; 14(1):e1006798.

Pseudomonas aeruginosa exoproducts determine antibiotic efficacy against Staphylococcus aureus.

Authors: Radlinski L, Rowe SE, Kartchner LB, Maile R, Cairns BA, Vitko NP, Gode CJ, Lachiewicz AM, Wolfgang MC, Conlon BP.
Reference: PLoS Biol. 2017 Nov; 15(11):e2003981.

Primary and Secondary Sequence Structure Requirements for Recognition and Discrimination of Target RNAs by Pseudomonas aeruginosa RsmA and RsmF.

Authors: Schulmeyer KH, Diaz MR, Bair TB, Sanders W, Gode CJ, Laederach A, Wolfgang MC, Yahr TL.
Reference: J Bacteriol. 2016 Sep 15; 198(18):2458-69.

Phosphoryl Group Flow within the Pseudomonas aeruginosa Pil-Chp Chemosensory System: DIFFERENTIAL FUNCTION OF THE EIGHT PHOSPHOTRANSFERASE AND THREE RECEIVER DOMAINS.

Authors: Silversmith RE, Wang B, Fulcher NB, Wolfgang MC, Bourret RB.
Reference: J Biol Chem. 2016 Aug 19; 291(34):17677-91.

Vfr Directly Activates exsA Transcription To Regulate Expression of the Pseudomonas aeruginosa Type III Secretion System.

Authors: Marsden AE, Intile PJ, Schulmeyer KH, Simmons-Patterson ER, Urbanowski ML, Wolfgang MC, Yahr TL.
Reference: J Bacteriol. 2016 May; 198(9):1442-50.

Production of extended-spectrum β-lactamases and the potential indirect pathogenic role of Prevotella isolates from the cystic fibrosis respiratory microbiota.

Authors: Sherrard LJ, McGrath SJ, McIlreavey L, Hatch J, Wolfgang MC, Muhlebach MS, Gilpin DF, Elborn JS, Tunney MM.
Reference: Int J Antimicrob Agents. 2016 Feb; 47(2):140-5.

The Role of Short-Chain Fatty Acids, Produced by Anaerobic Bacteria, in the Cystic Fibrosis Airway.

Authors: Mirković B, Murray MA, Lavelle GM, Molloy K, Azim AA, Gunaratnam C, Healy F, Slattery D, McNally P, Hatch J, Wolfgang M, Tunney MM, Muhlebach MS, Devery R, Greene CM, McElvaney NG.
Reference: Am J Respir Crit Care Med. 2015 Dec 1;192(11):1314-24.

The RNA Helicase DeaD Stimulates ExsA Translation To Promote Expression of the Pseudomonas aeruginosa Type III Secretion System.

Authors: Intile PJ, Balzer GJ, Wolfgang MC, Yahr TL.
Reference: J Bacteriol.2015 Aug;197(16):2664-74.

A hierarchical cascade of second messengers regulates Pseudomonas aeruginosa surface behaviors.

Authors: Luo Y, Zhao K, Baker AE, Kuchma SL, Coggan KA, Wolfgang MC, Wong GC, O’Toole GA.
Reference: mBio. 2015 Jan 27;6(1).

Mechanisms of reduced susceptibility and genotypic prediction of antibiotic resistance in Prevotella isolated from cystic fibrosis (CF) and non-CF patients.

Authors: Sherrard LJ, Schaible B, Graham KA, McGrath SJ, McIlreavey L, Hatch J, Wolfgang MC, Muhlebach MS, Gilpin DF, Schneiders T, Elborn JS, Tunney MM.
Reference: J Antimicrob Chemother. 2014 Oct;69(10):2690-8.

Flagellin treatment prevents increased susceptibility to systemic bacterial infection after injury by inhibiting anti-inflammatory IL-10+ IL-12- neutrophil polarization.

Authors: Neely CJ, Kartchner LB, Mendoza AE, Linz BM, Frelinger JA, Wolfgang MC, Maile R, Cairns BA.
Reference: PLoS One. 2014;9(1):e85623.

The AlgZR two-component system recalibrates the RsmAYZ posttranscriptional regulatory system to inhibit expression of the Pseudomonas aeruginosa type III secretion system.

Authors: Intile PJ, Diaz MR, Urbanowski ML, Wolfgang MC, Yahr TL.
Reference: J Bacteriol. 2014 Jan;196(2):357-66.

Antibiotic resistance in Prevotella species isolated from patients with cystic fibrosis.

Authors: Sherrard LJ, Graham KA, McGrath SJ, McIlreavey L, Hatch J, Muhlebach MS, Wolfgang MC, Gilpin DF, Elborn JS, Schneiders T, Tunney MM.
Reference: J Antimicrob Chemother. 2013 Oct;68(10):2369-74.

An unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa.

Authors: Marden JN, Diaz MR, Walton WG, Gode CJ, Betts L, Urbanowski ML, Redinbo MR, Yahr TL, Wolfgang MC.
Reference: Proc Natl Acad Sci USA. 2013 Sep 10;110(37):15055-60.

Lung microbiota and bacterial abundance in patients with bronchiectasis when clinically stable and during exacerbation.

Authors: Tunney MM, Einarsson GG, Wei L, Drain M, Klem ER, Cardwell C, Ennis M, Boucher RC, Wolfgang MC, Elborn JS.
Reference: Am J Respir Crit Care Med. 2013 May 15;187(10):1118-26.

The adult cystic fibrosis airway microbiota is stable over time and infection type, and highly resilient to antibiotic treatment of exacerbations.

Authors: Fodor AA, Klem ER, Gilpin DF, Elborn JS, Boucher RC, Tunney MM, Wolfgang MC.
Reference: PLoS One. 2012;7(9):e45001.

Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation.

Authors: Livraghi-Butrico A, Kelly EJ, Klem ER, Dang H, Wolfgang MC, Boucher RC, Randell SH, O’Neal WK.
Reference: Mucosal Immunol. 2012 Jul;5(4):397-408.

Significance of the microbiome in obstructive lung disease.

Authors: Han MK, Huang YJ, Lipuma JJ, Boushey HA, Boucher RC, Cookson WO, Curtis JL, Erb-Downward J, Lynch SV, Sethi S, Toews GB, Young VB, Wolfgang MC, Huffnagle GB, Martinez FJ.
Reference: Thorax. 2012 May;67(5):456-63.

Global regulatory pathways and cross-talk control Pseudomonas aeruginosa environmental lifestyle and virulence phenotype.

Authors: Coggan KA, Wolfgang MC.
Reference: Curr Issues Mol Biol. 2012;14(2):47-70.

Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa.

Authors: Topal H, Fulcher NB, Bitterman J, Salazar E, Buck J, Levin LR, Cann MJ, Wolfgang MC, Steegborn C.
Reference: J Mol Biol. 2012 Feb 17;416(2):271-86.

Pseudomonas aeruginosa PilY1 binds integrin in an RGD- and calcium-dependent manner.

Authors: Johnson MD, Garrett CK, Bond JE, Coggan KA, Wolfgang MC, Redinbo MR.
Reference: PLoS One. 2011;6(12):e29629.

Use of culture and molecular analysis to determine the effect of antibiotic treatment on microbial community diversity and abundance during exacerbation in patients with cystic fibrosis.

Authors: Tunney MM, Klem ER, Fodor AA, Gilpin DF, Moriarty TF, McGrath SJ, Muhlebach MS, Boucher RC, Cardwell C, Doering G, Elborn JS, Wolfgang MC.
Reference: Thorax. 2011 Jul;66(7):579-84.

Analysis of the bacterial communities present in lungs of patients with cystic fibrosis from American and British centers.

Authors: Stressmann FA, Rogers GB, Klem ER, Lilley AK, Donaldson SH, Daniels TW, Carroll MP, Patel N, Forbes B, Boucher RC, Wolfgang MC, Bruce KD.
Reference: J Clin Microbiol. 2011 Jan;49(1):281-91.

The development of ciprofloxacin resistance in Pseudomonas aeruginosa involves multiple response stages and multiple proteins.

Authors: Su HC, Ramkissoon K, Doolittle J, Clark M, Khatun J, Secrest A, Wolfgang MC, Giddings MC.
Reference: Antimicrob Agents Chemother. 2010 Nov;54(11):4626-35.

Activation of the Pseudomonas aeruginosa AlgU regulon through mucA mutation inhibits cyclic AMP/Vfr signaling.

Authors: Jones AK, Fulcher NB, Balzer GJ, Urbanowski ML, Pritchett CL, Schurr MJ, Yahr TL, Wolfgang MC.
Reference: J Bacteriol. 2010 Nov;192(21):5709-17.

Infection of human mucosal tissue by Pseudomonas aeruginosa requires sequential and mutually dependent virulence factors and a novel pilus-associated adhesin.

Authors: Heiniger RW, Winther-Larsen HC, Pickles RJ, Koomey M, Wolfgang MC.
Reference: Cell Microbiol. 2010 Aug;12(8):1158-73.

The Pseudomonas aeruginosa Vfr regulator controls global virulence factor expression through cyclic AMP-dependent and -independent mechanisms.

Authors: Fuchs EL, Brutinel ED, Jones AK, Fulcher NB, Urbanowski ML, Yahr TL, Wolfgang MC.
Reference: J Bacteriol. 2010 Jul;192(14):3553-64.

In vitro and in vivo characterization of the Pseudomonas aeruginosa cyclic AMP (cAMP) phosphodiesterase CpdA, required for cAMP homeostasis and virulence factor regulation.

Authors: Fuchs EL, Brutinel ED, Klem ER, Fehr AR, Yahr TL, Wolfgang MC.
Reference: J Bacteriol. 2010 Jun;192(11):2779-90.

The Pseudomonas aeruginosa Chp chemosensory system regulates intracellular cAMP levels by modulating adenylate cyclase activity.

Authors: Fulcher NB, Holliday PM, Klem E, Cann MJ, Wolfgang MC.
Reference: Mol Microbiol. 2010 May;76(4):889-904.

Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility.

Authors: Orans J, Johnson MD, Coggan KA, Sperlazza JR, Heiniger RW, Wolfgang MC, Redinbo MR.
Reference: Proc Natl Acad Sci USA. 2010 Jan 19;107(3):1065-70.

Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1.

Authors: Martino ME, Olsen JC, Fulcher NB, Wolfgang MC, O’Neal WK, Ribeiro CM.
Reference: J Biol Chem. 2009 May 29;284(22):14904-13.

Pseudomonas aeruginosa AlgR controls cyanide production in an AlgZ-dependent manner.

Authors: Cody WL, Pritchett CL, Jones AK, Carterson AJ, Jackson D, Frisk A, Wolfgang MC, Schurr MJ.
Reference: J Bacteriol. 2009 May;191(9):2993-3002.

Detection of anaerobic bacteria in high numbers in sputum from patients with cystic fibrosis.

Authors: Tunney MM, Field TR, Moriarty TF, Patrick S, Doering G, Muhlebach MS, Wolfgang MC, Boucher R, Gilpin DF, McDowell A, Elborn JS.
Reference: Am J Respir Crit Care Med. 2008 May 1;177(9):995-1001.

Genetic and functional analyses of PptA, a phospho-form transferase targeting type IV pili in Neisseria gonorrhoeae.

Authors: Naessan CL, Egge-Jacobsen W, Heiniger RW, Wolfgang MC, Aas FE, Røhr A, Winther-Larsen HC, Koomey M.
Reference: J Bacteriol. 2008 Jan;190(1):387-400.

Pseudomonas aeruginosa Type IV pilus expression in Neisseria gonorrhoeae: effects of pilin subunit composition on function and organelle dynamics.

Authors: Winther-Larsen HC, Wolfgang MC, van Putten JP, Roos N, Aas FE, Egge-Jacobsen WM, Maier B, Koomey M.
Reference: J Bacteriol. 2007 Sep;189(18):6676-85.

Substitutions in the N-terminal alpha helical spine of Neisseria gonorrhoeae pilin affect Type IV pilus assembly, dynamics and associated functions.

Authors: Aas FE, Winther-Larsen HC, Wolfgang M, Frye S, Løvold C, Roos N, van Putten JP, Koomey M.
Reference: Mol Microbiol. 2007 Jan;63(1):69-85.

Transcriptional regulation of the Pseudomonas aeruginosa type III secretion system.

Authors: Yahr TL, Wolfgang MC.
Reference: Mol Microbiol. 2006 Nov;62(3):631-40.

Bacterial neuraminidase facilitates mucosal infection by participating in biofilm production.

Authors: Soong G, Muir A, Gomez MI, Waks J, Reddy B, Planet P, Singh PK, Kaneko Y, Wolfgang MC, Hsiao YS, Tong L, Prince A.
Reference: J Clin Invest. 2006 Aug;116(8):2297-2305.

Acquisition and evolution of the exoU locus in Pseudomonas aeruginosa.

Authors: Kulasekara BR, Kulasekara HD, Wolfgang MC, Stevens L, Frank DW, Lory S.
Reference: J Bacteriol. 2006 Jun;188(11):4037-50.

The alternative sigma factor AlgT represses Pseudomonas aeruginosa flagellum biosynthesis by inhibiting expression of fleQ.

Authors: Tart AH, Wolfgang MC, Wozniak DJ.
Reference: J Bacteriol. 2005 Dec;187(23):7955-62.

Genome-wide analysis of host responses to the Pseudomonas aeruginosa type III secretion system yields synergistic effects.

Authors: Ichikawa JK, English SB, Wolfgang MC, Jackson R, Butte AJ, Lory S.
Reference: Cell Microbiol. 2005 Nov;7(11):1635-46.

A conserved set of pilin-like molecules controls type IV pilus dynamics and organelle-associated functions in Neisseria gonorrhoeae.

Authors: Winther-Larsen HC, Wolfgang M, Dunham S, van Putten JP, Dorward D, Løvold C, Aas FE, Koomey M.
Reference: Mol Microbiol. 2005 May;56(4):903-17.

A novel anti-anti-activator mechanism regulates expression of the Pseudomonas aeruginosa type III secretion system.

Authors: Dasgupta N, Lykken GL, Wolfgang MC, Yahr TL.
Reference: Mol Microbiol. 2004 Jul;53(1):297-308.

Type IV pilus retraction in pathogenic Neisseria is regulated by the PilC proteins.

Authors: Morand PC, Bille E, Morelle S, Eugène E, Beretti JL, Wolfgang M, Meyer TF, Koomey M, Nassif X.
Reference: EMBO J. 2004 May 5;23(9):2009-17.

Pseudomonas aeruginosa regulates flagellin expression as part of a global response to airway fluid from cystic fibrosis patients.

Authors: Wolfgang MC, Jyot J, Goodman AL, Ramphal R, Lory S.
Reference: Proc Natl Acad Sci USA. 2004 Apr 27;101(17):6664-8.

Sequence polymorphism in the glycosylation island and flagellins of Pseudomonas aeruginosa.

Authors: Arora SK, Wolfgang MC, Lory S, Ramphal R.
Reference: J Bacteriol. 2004 Apr;186(7):2115-22.

The multi-talented bacterial adenylate cyclases.

Authors: Lory S, Wolfgang M, Lee V, Smith R.
Reference: Int J Med Microbiol. 2004 Apr;293(7-8):479-82.

Effect of metabolic imbalance on expression of type III secretion genes in Pseudomonas aeruginosa.

Authors: Rietsch A, Wolfgang MC, Mekalanos JJ.
Reference: Infect Immun. 2004 Mar;72(3):1383-90.

An adenylate cyclase-controlled signaling network regulates Pseudomonas aeruginosa virulence in a mouse model of acute pneumonia.

Authors: Smith RS, Wolfgang MC, Lory S.
Reference: Infect Immun. 2004 Mar;72(3):1677-84.

A four-tiered transcriptional regulatory circuit controls flagellar biogenesis in Pseudomonas aeruginosa.

Authors: Dasgupta N, Wolfgang MC, Goodman AL, Arora SK, Jyot J, Lory S, Ramphal R.
Reference: Mol Microbiol. 2003 Nov;50(3):809-24.

Conservation of genome content and virulence determinants among clinical and environmental isolates of Pseudomonas aeruginosa.

Authors: Wolfgang MC, Kulasekara BR, Liang X, Boyd D, Wu K, Yang Q, Miyada CG, Lory S.
Reference: Proc Natl Acad Sci USA. 2003 Jul 8;100(14):8484-9.

Coordinate regulation of bacterial virulence genes by a novel adenylate cyclase-dependent signaling pathway.

Authors: Wolfgang MC, Lee VT, Gilmore ME, Lory S.
Reference: Dev Cell. 2003 Feb;4(2):253-63.

Type IV pili are not specifically required for contact dependent translocation of exoenzymes by Pseudomonas aeruginosa.

Authors: Sundin C, Wolfgang MC, Lory S, Forsberg A, Frithz-Lindsten E.
Reference: Microb Pathog. 2002 Dec;33(6):265-77.

Competence for natural transformation in Neisseria gonorrhoeae: components of DNA binding and uptake linked to type IV pilus expression.

Authors: Aas FE, Wolfgang M, Frye S, Dunham S, Løvold C, Koomey M.
Reference: Mol Microbiol. 2002 Nov;46(3):749-60.

Modification of type IV pilus-associated epithelial cell adherence and multicellular behavior by the PilU protein of Neisseria gonorrhoeae.

Authors: Park HS, Wolfgang M, Koomey M.
Reference: Infect Immun. 2002 Jul;70(7):3891-903.

Neisseria gonorrhoeae PilV, a type IV pilus-associated protein essential to human epithelial cell adherence.

Authors: Winther-Larsen HC, Hegge FT, Wolfgang M, Hayes SF, van Putten JP, Koomey M.
Reference: Proc Natl Acad Sci USA. 2001 Dec 18;98(26):15276-81.

Structural alterations in a type IV pilus subunit protein result in concurrent defects in multicellular behaviour and adherence to host tissue.

Authors: Park HS, Wolfgang M, van Putten JP, Dorward D, Hayes SF, Koomey M.
Reference: Mol Microbiol. 2001 Oct;42(2):293-307.

Components and dynamics of fiber formation define a ubiquitous biogenesis pathway for bacterial pili.

Authors: Wolfgang M, van Putten JP, Hayes SF, Dorward D, Koomey M.
Reference: EMBO J. 2000 Dec 1;19(23):6408-18.

Charged tmRNA but not tmRNA-mediated proteolysis is essential for Neisseria gonorrhoeae viability.

Authors: Huang C, Wolfgang MC, Withey J, Koomey M, Friedman DI.
Reference: EMBO J. 2000 Mar 1;19(5):1098-107.

The comP locus of Neisseria gonorrhoeae encodes a type IV prepilin that is dispensable for pilus biogenesis but essential for natural transformation.

Authors: Wolfgang M, van Putten JP, Hayes SF, Koomey M.
Reference: Mol Microbiol. 1999 Mar;31(5):1345-57.

Suppression of an absolute defect in type IV pilus biogenesis by loss-of-function mutations in pilT, a twitching motility gene in Neisseria gonorrhoeae.

Authors: Wolfgang M, Park HS, Hayes SF, van Putten JP, Koomey M.
Reference: Proc Natl Acad Sci USA. 1998 Dec 8;95(25):14973-8.

PilT mutations lead to simultaneous defects in competence for natural transformation and twitching motility in piliated Neisseria gonorrhoeae.

Authors: Wolfgang M, Lauer P, Park HS, Brossay L, Hébert J, Koomey M.
Reference: Mol Microbiol. 1998 Jul;29(1):321-30.